Classic KTP Vacancy advertisement details

Reference: 3843/5

Location: Macclesfield, Cheshire, SK10 2NA
Salary: £32,236 per annum
Qualification required: PhD or equivalent in Chemistry or Physics
Closing Date: 26 March 2019
KTP Advert Ref: 3843/5
Full time (36.5 hours per week), 24 month fixed term contract.

A KTP Associate (Research Fellow) position is available in the Solid-State NMR group at the University of Warwick on a fixed term basis for a period of 24 months with a proposed start date of 1 July 2019.

The successful candidate will work in close collaboration with Professor Steven P. Brown (University of Warwick, Physics) and Dr Jozef R. Lewandowski (University of Warwick, Chemistry) and Dr Leslie P. Hughes and Dr Helen Blade (AstraZeneca, Macclesfield). The project will apply an NMR crystallography approach that is the combination of experimental solid-state NMR, X-ray diffraction and density-functional theory computation of NMR parameters, to characterise pharmaceutical systems exhibiting disorder in the solid state. The candidate must possess experience of NMR crystallography, both experiment and calculation. The position will be based at the AstraZeneca Campus (Macclesfield), working in a multi-disciplinary team, but will require some visits to the University of Warwick.

The Solid State NMR group at Warwick (http://go.warwick.ac.uk/nmr) is extremely well-equipped with 10 solid state NMR spectrometers, a very wide range of probes, a large and diverse portfolio of research activity, and an excellent track record of collaboration with other research groups both nationally and internationally. Most of the group’s solid-state NMR infrastructure is accommodated in a purpose-built laboratory in Millburn House that also hosts the UK High-Field Solid-State NMR Facility (an EPSRC National Research Facility, with an 850 MHz instrument and a 1 GHz system to be delivered in early 2020). For informal enquiries please contact Steven P. Brown (S.P.Brown@warwick.ac.uk).

AstraZeneca is a leading global biopharmaceutical company with a passion for science (https://www.astrazeneca.com). This position will be based in AstraZeneca’s Pharmaceutical Research & Development function. The department has state of the art facilities for solid state characterisation of pharmaceuticals including 7 NMR spectrometers (2 solid state), X-ray diffraction and thermal methods.

Expected interview date: 2 April 2019.

JOB PURPOSE

The Associate will apply NMR crystallography methodology to characterise pharmaceutical systems exhibiting disorder in the solid state in this Knowledge Transfer Partnership (KTP) project between the Solid-State NMR Group at the University of Warwick (Departments of Physics and Chemistry) and the global biopharmaceutical company, AstraZeneca (Macclesfield). The Associate will be expected to work mostly at AstraZeneca’s Research & Development Campus in Macclesfield, making some visits to University of Warwick. The project will involve working on model systems as well as compounds currently in development.

DUTIES & RESPONSIBILITIES

1. To provide NMR crystallography expertise to the Knowledge Transfer Partnership (KTP) project between the Solid State NMR Group at University of Warwick and AstraZeneca (Macclesfield).

2. Under the direction of Professor Steven P. Brown (University of Warwick, Physics) and Dr Jozef R. Lewandowski (University of Warwick, Chemistry) and Dr Leslie P. Hughes and Dr Helen Blade (Astra Zeneca, Macclesfield), the KTP Associate will apply an NMR crystallography approach, that is the combination of experimental solid-state NMR, X-ray diffraction and density-functional theory computation of NMR parameters, to characterise pharmaceutical systems exhibiting disorder in the solid state.

3. To introduce and embed the NMR crystallography approach into AstraZeneca’s suite of frontline characterisation techniques for disordered solid-state pharmaceutical products.

4. To disseminate, teach and transfer the basic underpinning knowledge of the NMR crystallography approach to the relevant research and technical staff within AstraZeneca to thus maximise the broad-based impact of the research project.

Further Particulars
The University

For further information about the University of Warwick, please read our University Further Particulars.

The Department of Physics

For further information about the department, please visit the departmental website.

The Physics Department and the University of Warwick are proud of their diverse community of staff, students, and visitors, and are committed to maintaining an excellent record in teaching and research by ensuring that there is equality of opportunity for all, fostered in an environment of mutual respect and dignity.

Both the Physics Department and the University of Warwick hold Athena SWAN Silver awards, a national initiative to promote gender equality for all staff and students. The Physics Department is also a Juno Champion, which is an award from the Institute of Physics to recognise our efforts to address the under-representation of women in university physics and to encourage better practice for both women and men.

Further information can be found at https://www.warwick.ac.uk/physics/staff/working/.

The University supports flexible working and requests for job-share will be considered where possible.

Childcare can be provided for you at the University of Warwick Nursery (http://www.warwick.ac.uk/services/childrensservices/nursery.) in order for you to attend the interview. Childcare is subject to availability of places at the Nursery.

This partnership received financial support from the Knowledge Transfer Partnerships (KTP) programme. KTP aims to help businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills that reside within the UK knowledge base. This successful Knowledge Transfer Partnership project, funded by UK Research and Innovation through Innovate UK, is part of the government’s Industrial Strategy.

Right to work in the UK

If you do not yet have the right to work in the UK and/ or are seeking sponsorship under Tier 2 of the UK points-based immigration system
please click on this link which contains further information about obtaining right to work in the UK and details about eligibility for sponsorship under Tier 2.

If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant on level 5 of the University grade structure (£29,515). Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of level 6 of the University grade structure (£30,395 pa).

Recruitment of Ex-Offenders Policy

As an organisation using the (DBS) Disclosure and Barring Service to assess applicants’ suitability for positions of trust, the University of Warwick complies with the DBS Code of Practice and undertakes not to discriminate unfairly against any subject of a Disclosure on the basis of a conviction or other information revealed. More information is available on the University’s Vacancy pages and applicants may request a copy of the DBS Code of Practice.

Other Information

The University of Warwick provides an inclusive working and learning environment, recognising and respecting every individual’s differences. We welcome applications from individuals who identify with any of the protected characteristics defined by the Equality Act 2010.


Skills required: The Person Specification focuses on the knowledge, skills, experience and qualifications required to undertake the role effectively. This is measured by (a) Application Form, (b) Test/Exercise, (c) Interview, (d) Presentation.

Essential Criteria 1
PhD or equivalent in Chemistry or Physics or related subject with a strong emphasis in experimental NMR crystallography approaches (a)

Essential Criteria 2
A recognised research programme in NMR crystallography and an internationally strong publication record (a,c)

Essential Criteria 3
Good organisational skills (a,c)

Essential Criteria 4
Excellent communication and presentation skills (a,c)

Essential Criteria 5
An ability to function in highly focussed multi-disciplinary teams within academic and industrial work environments engaging with both senior and junior staff members (a,c)

Essential Criteria 6
An understanding of equal opportunity issues as they may impact on areas of research content (a,c)

Desirable Criteria 1
A knowledge of the pharmaceutical development process for solid state forms and how differences in crystal structures can impact on product performance (a,c)

Desirable Criteria 2
Good experience of running DFT GIPAW calculations (a,c)

Desirable Criteria 3
A sound knowledge of complementary solid-state characterisation techniques, notably X-ray diffraction techniques (a,c)
Knowledge Base Partner: Warwick, The University of
Company partner: AstraZeneca UK Limited
Company business area: Pharmaceuticals.
Contact: Steven Brown, University of Warwick, Tel: N/A
S.P.Brown@warwick.ac.uk
Additional Info: None

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